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Steven A Krilis Selected Research

beta 2-Glycoprotein I (Apolipoprotein H)

9/2016Gram Negative Bacterial Inflammation Ameliorated by the Plasma Protein Beta 2-Glycoprotein I.
1/2016The Fifth Domain of Beta 2 Glycoprotein I Protects from Natural IgM Mediated Cardiac Ischaemia Reperfusion Injury.
1/2016Do Beta 2-Glycoprotein I Disulfide Bonds Protect the Human Retina in the Setting of Age-Related Macular Degeneration?
1/2016Posttranslational forms of beta 2-glycoprotein I in the pathogenesis of the antiphospholipid syndrome.
12/2014Laboratory methods to detect antiphospholipid antibodies.
4/2008Beta2-glycoprotein I protects thrombin from inhibition by heparin cofactor II: potentiation of this effect in the presence of anti-beta2-glycoprotein I autoantibodies.
2/2007Beta2-glycoprotein I binds thrombin via exosite I and exosite II: anti-beta2-glycoprotein I antibodies potentiate the inhibitory effect of beta2-glycoprotein I on thrombin-mediated factor XIa generation.
6/2004Effect of beta2-glycoprotein I null mutation on reproductive outcome and antiphospholipid antibody-mediated pregnancy pathology in mice.
12/2002Use of single point mutations in domain I of beta 2-glycoprotein I to determine fine antigenic specificity of antiphospholipid autoantibodies.
1/2002Heparin inhibits the binding of beta 2-glycoprotein I to phospholipids and promotes the plasmin-mediated inactivation of this blood protein. Elucidation of the consequences of the two biological events in patients with the anti-phospholipid syndrome.

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Steven A Krilis Research Topics

Disease

17Antiphospholipid Syndrome (Antiphospholipid Antibody Syndrome)
01/2022 - 01/2002
6Thrombosis (Thrombus)
01/2022 - 01/2004
5Inflammation (Inflammations)
11/2020 - 06/2012
3Macular Degeneration (Age-Related Maculopathy)
12/2018 - 01/2016
3Colitis
06/2014 - 01/2011
2Arthritis (Polyarthritis)
01/2017 - 06/2012
2Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
06/2012 - 01/2011
2Asthma (Bronchial Asthma)
07/2002 - 04/2002
1ST Elevation Myocardial Infarction
11/2020
1Coronary Artery Disease (Coronary Atherosclerosis)
11/2020
1Pregnancy Complications
01/2018
1Reperfusion Injury
01/2016
1Hypertension (High Blood Pressure)
01/2015
1Pre-Eclampsia (Preeclampsia)
01/2015
1Systemic Lupus Erythematosus (Libman-Sacks Disease)
08/2014
1Glomerulonephritis
08/2014
1Chronic Obstructive Pulmonary Disease (COPD)
06/2014
1Fibrosis (Cirrhosis)
06/2014
1Keloid
01/2014
1Hypertrophic Cicatrix (Hypertrophic Scar)
01/2014
1Experimental Arthritis
06/2012
1Venous Thrombosis (Deep-Vein Thrombosis)
09/2011
1Autoimmune Diseases (Autoimmune Disease)
09/2011
1Pathologic Constriction (Stenosis)
01/2011
1Coronary Disease (Coronary Heart Disease)
01/2011
1Weight Loss (Weight Reduction)
01/2011
1Rheumatic Diseases (Rheumatism)
07/2005
1Cellulitis
01/2005
1Exanthema (Rash)
01/2005
1Fetal Growth Retardation (Intrauterine Growth Retardation)
06/2004
1Fetal Weight
06/2004
1Respiratory Hypersensitivity
11/2002
1Mastocytosis
07/2002
1Mast-Cell Leukemia (Leukemia, Mast Cell)
07/2002
1Infections
04/2002
1Acquired Immunodeficiency Syndrome (AIDS)
04/2002

Drug/Important Bio-Agent (IBA)

10beta 2-Glycoprotein I (Apolipoprotein H)IBA
09/2016 - 01/2002
7AutoantibodiesIBA
12/2014 - 01/2002
6AutoantigensIBA
12/2014 - 01/2004
4AntibodiesIBA
01/2018 - 09/2003
4Tryptases (Tryptase)IBA
06/2014 - 11/2002
3AntigensIBA
01/2022 - 01/2002
3Sulfhydryl Compounds (Thiols)IBA
11/2020 - 09/2011
3Glycoproteins (Glycoprotein)IBA
08/2014 - 01/2004
3sodium sulfate (sodium bisulfate)FDA LinkGeneric
06/2014 - 01/2011
3Dextrans (Dextran)FDA Link
06/2014 - 01/2011
2C-Reactive ProteinIBA
11/2020 - 07/2005
2Complement Factor H (Factor H)IBA
12/2018 - 07/2017
2Phospholipids (Phosphatides)FDA LinkGeneric
01/2018 - 01/2002
2Blood Proteins (Serum Proteins)IBA
09/2016 - 01/2002
2Interleukin-6 (Interleukin 6)IBA
08/2014 - 06/2014
2Messenger RNA (mRNA)IBA
06/2014 - 07/2005
2Proteins (Proteins, Gene)FDA Link
06/2012 - 07/2002
2Antiphospholipid AntibodiesIBA
09/2011 - 06/2004
1FibrinIBA
01/2022
1Tyrosine (L-Tyrosine)FDA Link
07/2017
1Metalloproteases (Metalloproteinases)IBA
01/2017
1Fibronectins (Fibronectin)IBA
01/2017
1DisulfidesIBA
01/2016
1Immunoglobulin M (IgM)IBA
01/2016
1Biomarkers (Surrogate Marker)IBA
01/2015
1AngiotensinogenIBA
01/2015
1CytokinesIBA
08/2014
1Toll-Like Receptors (Toll-Like Receptor)IBA
08/2014
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
08/2014
1Toll-Like Receptor 7IBA
08/2014
1SmokeIBA
06/2014
1Methacholine Chloride (Methacholine)FDA Link
06/2014
1Serine Proteases (Serine Protease)IBA
01/2014
1Chymases (Chymase)IBA
01/2014
1Oxidoreductases (Dehydrogenase)IBA
09/2012
1Factor XI (Plasma Thromboplastin Antecedent)IBA
09/2012
1Guanine NucleotidesIBA
06/2012
1Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
01/2011
1Clopidogrel (Plavix)FDA Link
01/2011
1Sulfonic AcidsIBA
01/2011
1Thromboplastin (Tissue Factor)IBA
07/2005
1Thomsen-Friedenreich antigenIBA
07/2005
1Methadone (Dolophine)FDA LinkGeneric
01/2005
1Interleukin-4 Receptors (Interleukin 4 Receptor)IBA
11/2002
1SerpinsIBA
11/2002
1Interleukin-13IBA
11/2002
1Peptide Hydrolases (Proteases)FDA Link
11/2002
1InterleukinsIBA
11/2002
1Chemokine ReceptorsIBA
04/2002
1Interleukin-16 (Interleukin 16)IBA
04/2002
1Biological ProductsIBA
01/2002

Therapy/Procedure

1Intravenous Administration
01/2022
1Lasers (Laser)
01/2022